The Arizona Cardinals will face several different starters from the San Francisco 49ers team they beat 47-7 in Week 3 of the regular season.
Blaine Gabbert is in at quarterback for the 49ers. Colin Kaepernick, whom Arizona intercepted four times and returned two takeaways for touchdowns in the lopsided game, was placed on Injured Reserve last week.
Even with multiple personnel changes on both sides of the ball, San Francisco's coordinators sounded optimistic about their team's chances of winning a seventh consecutive home game against their divisional foe.
"We're excited about playing Arizona," offensive coordinator Geep Chryst said on Friday.