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Big questions await the 49ers as NFL Combine approaches; could there be a surprise pick?

The annual NFL Scouting Combine begins next week in Indianapolis, meaning the 49ers’ brain trust is evaluating prospects’ game film and figuring out what questions need asking before they get up close and personal through private interviews and medical examinations.

It’s clear San Francisco has needs at pass rusher, receiver, linebacker and in the secondary — some of which could be answered through free agency by way of $65 million in salary-cap space.

But their most important decision could come down to the No. 2 overall pick, which will have ramifications for years as coach Kyle Shanahan and general manager John Lynch look to field a winning roster for the first time since being hired in 2017.