The 49ers recently re-signed eight of the 10 players who finished the season on the team’s practice squad.
Wide receiver DeAndre Smelter, who was not among the first wave of 49ers signings to 2018 contracts, signed Wednesday with the Indianapolis Colts, ending his three-season association with the organization.
Smelter was one of general manager Trent Baalke’s redshirt draft picks. The team selected him in the fourth round of the 2015 draft despite a torn ACL that ended his final season at Georgia Tech.
Smelter spent his first season on an injured list. He was waived at the beginning of the past two seasons, finishing both years on the 49ers’ practice squad.