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Are the 49ers missing too many tackles defensively?

The San Francisco 49ers had a weekend to forget in Week 5 against the Arizona Cardinals, losing a 24-23 game to fall to 2-3 on the year.

While much of the blame resorted to the offense, and deservedly so, the defense had one clear issue, which was really seen as the game went along: missed tackles.

Overall, San Francisco has seen 29 missed tackles over their past two weeks, while seeing 43 missed tackles over the whole year.

Why has it been a recurring issue for the 49ers this year?

“I wouldn’t say it’s fatigue,” defensive coordinator Nick Sorensen said earlier this week.