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Are teams defending the 49ers differently without Christian McCaffrey?

The San Francisco 49ers are slated to face off against the Arizona Cardinals this weekend in another divisional showdown, as they’ll look to build off their 30-13 victory over the New England Patriots from Week 4.

As they do so, the 49ers are dealing with a few notable injuries, as Fred Warner, George Kittle, Yetur-Gross Matos, Dee Winters, Jacob Cowing, and Chris Conley have all yet to practice this week, placing their availability into question for Week 5.

However, the biggest injury that looms around the team is still star running back Christian McCaffrey, with there being a number of questions about his recovery and when he’ll ultimately return to the field.