The one constant in the NFL is change. Between 2013 and 2014, the San Francisco 49ers lost Jonathan Goodwin, Carlos Rogers, Donte Whitner and Tarell Brown from their starting lineup. It looks like they’ll be hit even harder this season, with previous opening-day starters Michael Crabtree, Mike Iupati, Frank Gore, Ray McDonald, Justin Smith, Patrick Willis and Chris Culliver all having left the team this offseason.
By the time the 2016 season starts, another batch of players will be replaced. While we don’t have a crystal ball here at Bleacher Report HQ, we can certainly try to identify which players have make-or-break seasons upcoming.