The Cardinals' offense has had quite the eventful week after losing Zach Ertz for the season to a knee injury on Sunday and releasing second-string running back Eno Benjamin. Kyler Murray is at risk of missing his second game in a row as well but is a game-time decision with a hamstring injury.
The 49ers' defense, on the other hand, has returned to form, holding the Rams and Chargers to 461 combined yards the last two weeks after a blip in the radar against the Chiefs.
Here are the five players to watch on the 49ers' defense as they take on the Cardinals on Monday night:
S Talanoa Hufanga
Talanoa Hufanga made his second career start with the 49ers against these same Cardinals last season in almost the same scenario.