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5 matchups 49ers must win on Monday Night Football vs. Seahawks

After a short week to prepare against the Arizona Cardinals and holding onto the win, the San Francisco 49ers now get the long week to prepare against their nemesis in the Seattle Seahawks for Week 10.

If the Niners win, they will be 9-0 to the Seahawks’ 7-3, and will have a real stranglehold on the NFC West and therefore an all-but guaranteed playoff spot.

Unfortunately, just as the 49ers began to welcome back their starters back from injury, they lost a very integral part of the defense when they lost linebacker Kwon Alexander for the season.