ESPN’s Field Yates reported the 49ers worked out three running backs Tuesday as their backfield is banged up. Elijah Mitchell is in the concussion protocol after taking a knee to the helmet. Mitchell also looked as though he rolled may have rolled his ankle on the same play. Mitchell is as tough as they come. I'd expect Mitchell to play despite nursing four separate injuries this season if he’s cleared from the protocol.
As Kyle Shanahan confirmed, it’s unclear when it happened, but Jeff Wilson’s knee flared up against the Seahawks. With rookie Trey Sermon on the injured reserve with a high-ankle sprain, that leaves JaMycal Hasty as the lone healthy running back.