Ryan Tannehill will have wide receiver A.J. Brown back in the lineup after three games. The Titans' offense reaches another level with Brown on the field. They’re 7-1 if Brown starts and finishes the game. Since this is Brown’s first game back from a chest injury, we’ll see if he’s limited. Also, who knows if Brown is 100%.
If the 49ers pressure Ryan Tannehill, he goes from a competent quarterback to a guy who looks lost. Tannehill’s passer rating this season is 54.0 when pressured, with ten turnover-worthy throws to go with six interceptions and three touchdowns.