Matthew Stafford #9 (center) of the Detroit Lions is sacked by Ian Williams #93 and Ahmad Brooks #55 of the San Francisco 49ers (Photo by Mark Cunningham/Detroit Lions/Getty Images)
The 49ers kick off their 2021 regular-season campaign against the Lions, and starting off with a win should hinge on the defensive efforts.
For the first time on the regular-season schedule, fans will get to see whether or not the San Francisco 49ers‘ preseason dominance on defense will count when it matters most.
The Niners defense ranked second in the NFL during the exhibition phase with an average of only 188.