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49ers vs. Bills: The Good, Bad and Ugly from San Francisco’s 45-16 Week 6 Loss

Where have you heard this story before — the San Francisco 49ers suffer an embarrassing defeat against a team which ran the ball like crazy against a porous Niners defense.

Well, it happened again. This time in Week 6 on the road against the Buffalo Bills.

San Francisco now drops to 1-5 after suffering an embarrassing 45-16 defeat at the hands of running back LeSean McCoy and a stout Buffalo defense.

Bills head coach Rex Ryan’s game plan should have been simple — give McCoy the ball early and often. And it worked. McCoy rushed for 140 yards on 19 carries and three touchdowns.