The NFL will slowly release the marquee matchups ahead of the official schedule release. Wednesday morning, the league announced five international games for 2022. Three games will take place in London during October.
In November, the Seattle Seahawks will play the Tampa Bay Buccaneers in Munich, Germany. On November 21, a Monday night, the 49ers will face the Cardinals in Mexico City.
This will count as a road game for San Francisco, thankfully. So, the 49ers will still have nine games at Levi’s Stadium, plus seven road games, then this game against the Cardinals at Estadio Azteca.