The San Francisco 49ers 2016 schedule features a host of tough opponents, and numerous measurements indicate it could be among the toughest in the NFL. We've heard plenty about the 49ers facing the highest opponent winning percentage. However, Bill Barnwell pointed to another measurement.
According to projected Pythagorean Expectation, the 49ers face the toughest schedule across the league. The 49ers have a similar schedule to that of the Los Angeles Rams, but Barnwell says, "The difference between the two? The Rams get to play the 49ers twice while San Francisco, sadly, cannot play itself.