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49ers run defense going ‘all gas’ mode

SANTA CLARA — Loss No. 1 of 14 last season previewed how historically terrible the 49ers run defense would be.

Remember when Fozzy Whittaker replaced an injured Jonathan Stewart and ran for 100 yards in that 46-27 loss at Carolina? Remember how that started a NFL-record streak of futility: the 49ers allowed a 100-yard rusher in seven straight games?

Game No. 1 this season should reveal a lot, too, and not just because it comes against the same opponent, the Panthers, on Sunday at Levi’s Stadium.

CHARLOTTE, NC - SEPTEMBER 18: Cam Newton #1 of the Carolina Panthers runs the ball against the San Francisco 49ers in the 3rd quarter during the game at Bank of America Stadium on September 18, 2016 in Charlotte, North Carolina. (Photo by Grant Halverson/Getty Images)
Panthers quarterback Cam Newton runs against the San Francisco 49ers last season.