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49ers RB Isaac Guerendo should get more opportunities in Week 3

The San Francisco 49ers enter Week 3 dealing with a number of injuries, as wide receiver Deebo Samuel and running back Christian McCaffrey won’t play, while tight end George Kittle is doubtful entering the weekend.

As a result, the 49ers will need to find other sources of offense against the Los Angeles Rams, and that could mean relying more on the running game.

San Francisco has a favorable matchup ahead of them on the ground, as the Rams are allowing 197 rushing yards per game and 5.5 yards per carry, both of which are third-worst in the NFL.