The San Francisco 49ers made a major move up in the 2024 NFL Draft when they traded up 44 spots to select Louisville running back Isaac Guerendo with the No. 129 pick in the fourth round.
Guerendo, who shined at the 2024 NFL Scouting Combine with a 4.33 40-yard dash, had been a player to watch, as his one-cut style and blazing speed fit what the 49ers wanted to do.
But, there were questions about whether the 49ers would end up taking a running back in the draft, given the talent at the position with Christian McCaffrey as the headliner.