Tackle Joe Staley, cornerback K'Waun Williams and recently signed receiver Louis Murphy are among the 49ers who will be in uniform against the Giants.
Staley suffered a fractured orbital bone two weeks ago against the Eagles but will line up at his familiar left tackle spot. Staley will wear a visor that should protect his right eye.
His return will send Trent Brown back to right tackle. Rookie Erik Magnuson will be the team's swing tackle whil Zane Beadles will fill in if there's an injury at guard or center.
Williams has been out with a quadriceps injury; his replacement, Leon Hall, also is active as rookie cornerback Greg Mabin.