Rookie cornerback Ahkello Witherspoon will make his seventh straight start today for the 49ers as he plays through a knee injury.
Witherspoon got hurt and couldn’t finish last Sunday’s win at Houston. Fellow defensive backs Greg Mabin (calf) and Antone Exum Jr. are both inactive.
Up from the practice squad to help the cornerback corps is Tyvis Powell, who’ll debut in uniform No. 45. The Titans have the league’s 27th-ranked passing attack as Marcus Mariota has produced 10 touchdown passes and 14 interceptions.
Also of note:
— Running back Jeremy McNichols is active for the first time.