Over at CBS Sports, John Breech recently broke down every NFL team’s strength of schedule in 2016 – based off of standings from a year ago. The 49ers, along with the Atlanta Falcons, topped the list with their opponents posting a combined 142-114 record for a .555 winning percentage.
The teeth of San Francisco’s schedule will come in six games. The 49ers have to face the Arizona Cardinals (13-3) and the Seattle Seahawks (10-6) twice in addition to matchups versus the Carolina Panthers (15-1) and New England Patriots (12-4). Those four teams are the only playoff clubs on the San Francisco's 2016 slate.