return from their bye week and will practice on Monday in preparation for the Jacksonville Jaguars (+2.5), who are also coming off their bye.
The Niners have opened as 2.5-point favorites for Week 10 with the total on the game set at 44.5 on DraftKings Sportsbook. Oddsmakers are expecting a 49er victory around the score of 23-20.
The 49ers have the third-highest point differential in the NFL at +78 while the Jags are eighth at +37. Trevor Lawrence is one of the most talented quarterbacks in the NFL and will pose a significant challenge for a Niners defense that struggled to get off the field before the bye.