The NFL announced the 2018 regular season schedule, and the San Francisco 49ers are opening on the road against the Minnesota Vikings. The Las Vegas SuperBook has quickly issued lines for Week 1, and they have installed the 49ers as 4.5-point underdogs. The point total has been set at 47.5.
A year ago, the 49ers opened as a 4.5-point underdog to the Carolina Panthers for Week 1. The line shifted a bit before settling at Carolina -1. The Panthers went on to win the game 23-3, snapping the 49ers six-game Week 1 win streak.