The 49ers open as 10-point favorites over the Seahawks for their Wild-Card showdown on Saturday afternoon, with the O/U set to 43.5 points on DraftKings SportsBook. The Sportsbooks in Las Vegas expect this to be a 49ers’ win by 27-17.
They were the biggest favorites of Wild-Card Weekend when the opening odds were announced, even bigger than the Bills (-9.5) over the Tua Tagovailoa-less Dolphins.
The 49ers have beaten the Seahawks twice this season. They beat them 27-7 at Levi’s Stadium when the 49ers were 8.5-point favorites with Trey Lance as starting quarterback and beat them 21-13 as three-point favorites in Seattle.