If rookie cornerback Ahkello Witherspoon learns a little more with every start, Sunday's figures to deliver a Master's-level course worth of knowledge.
Witherspoon and the rest of the 49ers' young secondary will be tasked with stopping the No. 2 receiver in the league this year, Houston's DeAndre Hopkins. He's been targeted 141 times and has 1,084 receiving yards, both of which lag behind only the Pittsburgh Steelers' Antonio Brown.
Witherspoon (Christian Brothers High School) noted that Hopkins is similar to Los Angeles Rams wideout Sammy Watkins -- both played at Clemson -- who had a season-high 106 receiving yards and two touchdowns when the Rams and 49ers played in Week 3.