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49ers notes: Breida mulls resting ankle; receivers rarely spotted

SANTA CLARA — Just when it appeared the 49ers were at their healthiest since the season opener, several players exited with injuries, starting with running back Matt Breida aggravating his left-ankle sprain on his first carry.

Breida fumbled on his next run, and he finished with five carries for 15 yards while giving way to Raheem Mostert and Alfred Morris. Both Shanahan and Breida said they’ll evaluate whether the second-year running back should sit out next Sunday’s game at Arizona to allow his ankle more time to recover from that initial sprain on Oct. 7.

“It’s something we have to look into hard,” Shanahan said.