The San Francisco 49ers travel to Detroit to open their 2021 campaign at Ford Field on Sunday afternoon when they take on the Lions. Sunday’s game will mark the third time the two teams have met to open the season in the Motor City since 1981. The previous two matchups were split with Detroit winning in 1981 and San Francisco winning in 1984. Those two seasons may ring a bell, as each would end with the 49ers hoisting the Lombardi Trophy.
This looks to be a lopsided affair. The oddsmakers have San Francisco near the top of the NFC while the Lions are at the bottom.