The San Francisco 49ers and New York Giants have met 42 times, including eight in the postseason. The two teams each have won 21. Thursday night’s contest at Levi’s Stadium in Santa Clara will break the deadlock. San Francisco comes in as 10.5 point favorites over a New York team which will be without four starters including star running back Saquon Barkley and the left side of its offensive line.
Here are my five burning questions for week 3.
1 Will the 49ers defense be able to contain Daniel Jones?
Justin Fields. Russell Wilson.