Captains of the San Francisco 49ers and the San Diego Chargers (Photo by Michael Zagaris/San Francisco 49ers/Getty Images) *** Local Caption ***
The 49ers play their second preseason game of 2021 this Saturday against the Chargers, and Niner Noise has your betting info right here.
The San Francisco 49ers travel for the first time in 2021 with a preseason Week 2 matchup against another AFC West team, the Los Angeles Chargers, for a bout in Southern California on Sunday, Aug. 22 at SoFI Stadium.
The Niners are coming off a 19-16 exhibition loss last Saturday to the Kansas City Chiefs, which saw rookie quarterback Trey Lance make his pro-level debut.