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49ers-Cardinals Week 5 odds: Niners open as 7.5-point favorites at home

The San Francisco 49ers bounced back nicely over the weekend, defeating the New England Patriots 30-13 to improve to 2-2 on the year.

Now, looking ahead to Week 5, the 49ers are looking to remain undefeated at home when they host the Arizona Cardinals at Levi’s Stadium, hoping to earn their first divisional win of the season.

Arizona has started the year 1-3, playing a tough Buffalo Bills team on the road in the opener before whooping the Los Angeles Rams 41-10 in Week 2. They’re coming off their roughest game yet, though, as the Cardinals just dropped a blowout 42-14 loss to the Washington Commanders at home in Week 4.