Back to the San Francisco 49ers Newsfeed

49ers-Bills Week 13 odds: The Niners are big underdogs in a must-win game

The San Francisco 49ers had their ugliest loss of the year on Sunday, dropping a 38-10 game to the Green Bay Packers to fall to 5-6 on the season.

After a close 20-17 loss to the Seattle Seahawks in Week 11 where the 49ers were in control for much of the game, San Francisco got out to a quick 17-0 deficit and never was within one score after the first two drives.

Now, looking ahead to Week 13, the 49ers will stay on the road for a matchup with the Buffalo Bills, who are coming off a bye week after a 30-21 win over the Kansas City Chiefs.