Fresh off their first loss of the season, the San Francisco 49ers (-7)
will look to regain their momentum in a Monday Night Football showdown with the Minnesota Vikings (+7) at U.S. Bank Stadium.
The 49ers, who stand at 5-1 on the year, suffered a disappointing defeat to the Cleveland Browns (-3.5)
, and could be without several key players as stars Trent Williams and Deebo Samuel have yet to practice this week.
The Vikings, on the other hand, stand at 2-4, coming off a 19-13 over the Chicago Bears (+2.