The 49ers followed up an ugly loss last week in Atlanta with their new worst loss of the season Sunday. The 44-23 loss to the Chiefs on Sunday was the fifth loss of 21 points or more in the Kyle Shanahan era and the first since Week 5 in 2020 against the Miami Dolphins.
There were no answers to Patrick Mahomes on either side of the ball for the 49ers, and the Chiefs showed just how far the 49ers are from being in the top tier of the league.
Here are the four losers and two winners from the 49ers' three-score loss to the Chiefs:
Winner: Christian McCaffrey
Maybe the loudest the crowd got today was when McCaffrey came in for the first time on the 49ers' third play from scrimmage.