The Week 2 NFL schedule for the 2021 season is stacked with great matchups, and we got you covered with what you need to know heading into the weekend. Our NFL Nation reporters bring us the biggest keys to every game, a bold prediction for each matchup and, of course, final score picks.
Additionally, ESPN Stats & Information provides a big statistic to know for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection.