Gone are James Shields, Melvin Upton Jr., Matt Kemp and Andrew Cashner. And their departures have cleared room for youngsters like Luis Perdomo and Hunter Renfroe.
With that in mind, here's an early look ahead to Opening Day 2017, slated for April 3 in Los Angeles.
OPPONENT: DODGERS
For the fourth consecutive season, the Padres will open with the Dodgers, and this time, they'll travel up Interstate 5 after being shut out by Los Angeles, 15-0, on Opening Day 2016.