Rzepczynski, a left-handed reliever, was acquired from the Indians before Friday's non-waiver Trade Deadline. He now returns to the West Coast, close to his high school roots in Anaheim where he played at Servite High, home of the Friars.
"Kind of interesting I get to do that," Rzepczynski said of playing for the Padres.
The Padres acquired the 29-year-old to give them a left-hander in the bullpen. They have not had one since Frank Garces was sent to Triple-A on July 8.
"You can survive without one, but it's more helpful to have one," said Padres interim manager Pat Murphy.