Luis Campusano was drafted by the Padres in the second round of the 2017 MLB Draft with the 39th pick. Originally committed to play baseball at the University of South Carolina, Campusano decided bypass his college ball to sign with San Diego for $1.3 million.
In 2018, he was named a Midwest League All-Star for the Fort Wayne TinCaps after he slashed .288/.345/.365 with three home runs and 40 RBIs in 70 games. His 2019 season was spent with the Lake Elsinore Storm where he played in 110 games total. Campusano hit 15 home runs and recorded 81 RBIs while finishing with a .