Patrick Mahomes' wife, Brittany, is at war with social media trolls once again ... this time, she's calling one of 'em out after a very offensive and triggering comment made on Instagram.
The remark was left under a photo of Brittany, her superstar husband, and their daughter, Sterling ... announcing they're expecting another baby.
The troll unleashed the disgusting comment in a reply to another user -- saying, "if I was stuck w this woman for life I'd kill myself.