Apparently nothing is off limits when it comes to Shannon Sharpe's trash talking -- not even Deion Sanders' horrifying foot ailments -- 'cause the Broncos legend roasted the hell out of Prime's amputated toes this week.
Shannon took his "Club Shay Shay" podcast on the road to Boulder, Colorado, to visit the new Buffs head coach ... and the jokes started flying almost immediately after he saw that Deion's foot was missing two of its toes.
"Man, where the big toe!?" Shannon asked Prime as the NFL legend was getting his surgically repaired foot massaged.