Jimmy Graham's NFL comeback has hit a roadblock -- the New Orleans Saints tight end was arrested on suspicion of being under the influence of a controlled substance Friday night ... after cops say they saw him wandering in traffic.
TMZ Sports has learned ... law enforcement responded to a call for a suspicious person acting erratically near a southern California resort.
At the scene, cops claim they witnessed Graham walking in the streets ... and they attempted to arrest him, but he resisted.
The 36-year-old was eventually taken into custody for suspicion of being under the influence of a controlled substance and resisting, delaying and obstructing a police officer -- both misdemeanors.