The 2022 NFL season will see some big spreads, and we’re highlighting the most lopsided ones for each week.
NFL Odds Wild Card Weekend: Biggest NFL Spreads This Week
| Rank | Matchup | Spread |
| 1 | Miami Dolphins vs. Buffalo Bills | Bills (-11) |
| 2 | Seattle Seahawks vs. San Francisco 49ers | 49ers (-10) |
| 3 | Baltimore Ravens vs. Cincinnati Bengals | Bengals (-6. |