Don Larsen -- the only pitcher in MLB history to ever throw a perfect game in the World Series -- died Wednesday ... Major League Baseball announced.
Larsen's agent, Andrew Levy, told the Associated Press the ex-New York Yankee passed away due to esphogeal cancer. He was 90 years old.
Larsen pitched for seven different teams during his 14-year MLB career from 1953-1967 ... but it was his performance in the 1956 World Series that he'll be forever remembered for.
The right-hander tossed a perfect game -- no hits and no walks allowed -- against the Brooklyn Dodgers in Game 5 of the Fall Classic.