Johnny Manziel's wife, Bre Tiesi, has DELETED all traces of the QB from her Instagram page -- and removed "Manziel" from her last name ... and all signs point to a breakup.
Unclear what triggered the move -- we're working on the story right now.
Bre just came back from a girls' trip to Bali while Johnny has been working on getting his football career back on track by signing with a team in the AAF league.
Obviously, SOMETHING happened ... we're trying to figure out what.
Bre and Johnny had been going strong for years .