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Indianapolis Colts vs. San Francisco 49ers, Line, Odds, Predictions, and Algorithm Picks from the SportsGrid Betting Model

As far as must-win games in Week 7 go, this is as big as it gets for the Indianapolis Colts (2-4) and the San Francisco 49ers (2-3) as both teams look to close in or catch the .500 mark.

Indianapolis Colts vs. San Francisco 49ers NFL Game Information

Colts (2-4) vs. 49ers (2-3)

Time: 8:20 PM ET

Levi’s Stadium

TV Coverage: NBC

Indianapolis Colts vs. San Francisco 49ers Moneyline, Spread, Total, and Odds

Moneyline: Colts +171 / 49ers -207

Spread: Colts +4 (-106) 49ers -4 (-112)

Total: 44 (-110)

Odds to Win NFL Championship: Colts +10000 49ers +4500

Odds courtesy of Fanduel Sportsbook.