Eminem just took a shot at Drew Brees on his new song -- saying "F***" the NFL QB ... presumably over his national anthem comments.
Em and Kid Cudi just dropped the new track at midnight Friday morning called, "The Adventures Of Moon Man & Slim Shady."
Marshall Mathers begins his verse about 1:50 into the track -- and drops this nugget:
"I had hoop dreams, now I shoot 3s.
Got a lil' green, but I don't do weed.
Purp nor lean, that's Tunechi.
That's New Orleans, F*** Drew Brees."
Of course Brees took a ton of heat for his stance on the national anthem and NFL protesters back in June -- saying, "I will never agree with anybody disrespecting the flag of the United States of America.