Deion Sanders is forbidding his Jackson State football players from leaving their Houston hotel room this weekend ... giving the demand in a heartfelt speech following Takeoff's tragic death.
The NFL Hall of Famer addressed the Migos rapper being shot and killed in Houston with his players on Tuesday ... pointing out the incident happened in the same city where they will play the Texas Southern Tigers on Saturday.
"Takeoff was murdered in a dice game in Houston -- where we're going," Sanders said.