Deandre Hopkins is putting serious pressure on his alma mater -- demanding Clemson remove the name of an infamous pro-slavery politician from its honors college ... RIGHT NOW!!!
The NFL star -- who played at Clemson from 2010 to 2012 -- says it's always made him sick to his stomach that his University still honors John C. Calhoun.
FYI, Calhoun was the Vice President of the United States from 1825 to 1832 under both John Quincy Adams and Andrew Jackson ... and STRONGLY advocated for slavery.