Ciara has Russell Wilson's back -- and also, clearly, his face -- 'cause while the two were on vacation in Italy this week ... she popped some of the pimples on the NFL star's cheeks!
The "Level Up" singer went to town on her hubby's mug on a boat in Lake Como on Tuesday -- after the Denver Broncos quarterback was seen complaining of some pimple pain.
Initially, Russ looked to try to handle the situation himself ... but seconds later, Ciara was spotted jumpin' into the mix for him.