If hoops don't work out for Blake Griffin ... he's got the official stamp of approval from comedian Nikki Glaser to move to the stand-up mic -- 'cause she's telling TMZ Sports Blake is LEGIT funny.
"Oh, he could totally be a comedian if he wanted to be," she says. "I wouldn't say that about anyone."
Remember ... Blake went head-to-head in a roast battle with Jeff Ross earlier this summer -- and killed it ... telling Jeff at one point, "You're such a bald piece of sh*t.