West Ham will give fitness tests before Friday's game to Andy Carroll and Arthur Masuaku, who are nursing respective groin and foot problems.
Diafra Sakho, Michail Antonio, Pedro Obiang and Angelo Ogbonna are all out for the season.
Tottenham's Danny Rose is not due to start full first-team training until next week so again misses out.
Erik Lamela, Harry Winks and Cameron Carter-Vickers are out for the rest of the campaign.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "I've said on the BBC that in 30 years of commentating on Spurs this is the closest I've seen to a Tottenham title-winning side.