Watford are set to be without Stefano Okaka, who picked up a hamstring injury during his Hornets' debut last weekend.
Reports suggest the Italian forward could be out for over a month.
Manchester United's Wayne Rooney, Antonio Valencia and Luke Shaw are back in the squad after being rested for the Europa League defeat in midweek.
Defender Eric Bailly will be assessed after receiving a knock in that game, while Henrikh Mkhitaryan is nursing a thigh problem.
MOTD COMMENTATOR'S NOTES
Steve Bower: "These two teams go into this one on the back of contrasting emotions.